The Position Verve is seeking a Scientist or Scientist II within the Analytical CMC team, to interface with Process Development, Internal and External Quality Control in developing, implementing, and transferring molecular and cell biology-based methods to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA. This individual will be interfacing with a cross-functional team to design, develop and support phase- appropriate qualification of analytical methods to enable Verve’s growing gene editing pipeline. Job Responsibilities Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high throughput analysis, and characterization of complex raw materials. Improve existing cell-based assays with a focus on improving robustness, reproducibility, and accuracy. Collaborate across multiple cross-functional teams to perform experiments and summarize work in presentations and technical reports. Author, review, and approve protocols, SOPs, technical reports, and sections of regulatory submissions. Perform laboratory experiments while providing leadership and mentorship to junior scientific team members. Continuously monitor the literature to identify gaps in existing methods and mobilize Verve resources to complete gap analysis. Act as an advisor to provide routine guidance to both the internal team and contract testing laboratories (CTL) to resolve technical problems. Review analytical data and provide feedback to both external and internal teams. Assist in continuous improvement activities. Develop and apply molecular biological methods, immunoassays, and other state of the art technologies to analyze and characterize cell and gene products. Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance. Maintain detailed documentation of experiments in ELN system Experience automating lab procedures is highly desirable. Other duties as assigned. Qualifications Hands on experience developing and troubleshooting analytical methods applied to complex and heterogenous systems. Deep understanding of cell-based assay development and validation, preferably with lipid nanoparticles. Experience in assay development, qualification, validation, and implementation to support target candidate validation from Non-GxP to GMP environments. A collaborative and proactive mindset, taking initiative to drive tasks to completion. Demonstrated experience in supervising and developing junior scientific team members. Scientist requirements: M.S. in Biochemistry, Molecular Biology and/or related life sciences field with strong scientific background and 4-7 years’ relevant experience or PhD and 0-2 years relevant experience . Scientist II requirements M.S. in Biochemistry, Molecular Biology and/or related life sciences field with strong scientific background and 7+ years’ relevant experience or PhD and 2+ years relevant experience . #J-18808-Ljbffr Verve Therapeutics
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